Welcome to Prof. Elisa Oricchio's LabISREC

Research in Oricchio Laboratory focuses on the genetics of lymphoma and its translation into new therapies. We combine genomic analyses of human tumors with functional in vivo studies to assess the role of genetic lesions in tumorigenesis, disease progression, and relapse under treatment. We use mosaic models of lymphomas to functionally annotate genes of interest identified by the genomic analyses and to perform pre-clinical treatment studies. We just published a study in which we investigated how recurrent mutations of EZH2 exploit the 3D organization of the genome to sustain oncogenic programs (see the video abstract below).